The GLP-1 Support Stack: Essential Supplements for Ozempic & Mounjaro Users

• Mechanism: GLP-1s slow digestion, which can reduce nutrient absorption rates. Liquid or highly bioavailable forms are superior.
• Critical Deficiencies: Vitamin B12, Magnesium, and Vitamin D are the most common drops seen in long-term users.
• Muscle Protection: High-quality protein and creatine are non-negotiable to prevent sarcopenia (muscle wasting).
• Nausea Control: Electrolytes without high sugar content are your first line of defense against the 'Ozempic flu.'

If you need immediate guidance, these are the current market leaders for GLP-1 support. We judge these based on bioavailability, ease of digestion, and additive transparency.

• Best Overall Support System: Metabolic Daily GLP-1 Pack. A 2026 release focusing on methylated B-vitamins and ginger root extract in a single sachet.
• Best for Nausea & Hydration: Liquid I.V. Sugar-Free Clinical. Still the gold standard for rapid electrolyte replenishment without the glucose spike.
• Best for Muscle Preservation: Thorne Amino Complex. Essential amino acids (EAAs) that digest easier than heavy whey powders during periods of low appetite.
• Best for 'Ozempic Face': Vital Proteins Bio-Active Peptides. Focused on skin elasticity to counteract rapid volume loss.

When you take a GLP-1 agonist, gastric emptying slows down significantly. This is great for feeling full, but it creates a bottleneck for oral supplements. In 2026, we know that dense, hard-pressed tablets often sit in the stomach too long, potentially causing irritation or degrading before they reach the small intestine where absorption happens.

The Solution: Switch to capsules, liquids, or sublingual sprays. These formats bypass the mechanical breakdown requirement of the stomach. For example, sublingual B12 enters the bloodstream directly through the tissues in the mouth, rendering gastric delays irrelevant. If you are tracking your intake using our Daily Vitamin Tracker, note the form of the vitamin alongside the dosage.

Clinical data from the last few years highlights three specific nutrients that tend to plummet during rapid weight loss phases.

1. Vitamin B12

Many users report fatigue not just from caloric deficit, but from B12 depletion. This vitamin is crucial for energy metabolism and nerve function. Since animal proteins (the main source of B12) can feel heavy in the stomach on these meds, supplementation is often necessary.

2. Magnesium

Magnesium deficiency exacerbates constipation-a notorious side effect of Ozempic. We recommend Magnesium Glycinate for its high absorption and gentle profile on the gut. For a deeper dive on which form to take, review our comparison on Magnesium Glycinate vs. Citrate.

3. Vitamin D3

As fat stores mobilize, fat-soluble vitamins like D3 can fluctuate. Maintaining optimal levels is vital for immune function and mood regulation.

Nausea often stems from a mix of low blood sugar and mild dehydration. Because you aren't eating as much food, you also aren't getting the hydration usually found in fruits and vegetables.

The Protocol:

• Morning: Start with 16oz of water mixed with a sodium-potassium-magnesium electrolyte powder. Avoid sports drinks with high fructose corn syrup.
• During Meals: Sip, don't gulp. Too much fluid with food expands the stomach and triggers nausea.

Use our Hydration Calculator to determine your baseline water needs, then add 20% to account for the metabolic shift.

The most concerning side effect of GLP-1s in 2026 is the loss of lean muscle mass. When you eat less, your body catabolizes muscle for fuel unless signaled otherwise.

Nutritional Strategy:

1. Prioritize Protein: Aim for 0.8g to 1g of protein per pound of ideal body weight. If solid food is unappealing, clear whey isolate drinks are lighter than shakes.
2. Creatine Monohydrate: Not just for bodybuilders. 5g daily helps preserve muscle tone and cognitive function during calorie restriction.

Unsure if you are hitting your targets? Input your current weight and activity level into our Protein Need Est tool to get a precise gram-target.

Rapid weight loss outpaces the skin's ability to retract, leading to laxity. While nutrition cannot fully replace surgical intervention for loose skin, it can improve elasticity. Collagen peptides combined with Vitamin C (necessary for collagen synthesis) provide the building blocks for skin repair.

We recently analyzed the bioavailability of different sources in our report on Collagen Peptides vs. Marine Collagen, which is essential reading for anyone concerned about facial volume loss.